Document Detail


The origins of the molecular era of adhesion research.
MedLine Citation:
PMID:  23151664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recognition of the importance of cell adhesion grew steadily during the twentieth century as it promised answers to fundamental questions in diverse fields that included cell biology, developmental biology, tumorigenesis, immunology and neurobiology. However, the route towards a better understanding of its molecular basis was long and difficult, with many false starts. Major progress was made in the late 1970s to late 1980s with the identification of the major families of adhesion molecules, including integrins and cadherins. This in turn set the stage for the explosive growth in adhesion research over the past 25 years.
Authors:
Alan Rick Horwitz
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-15
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  13     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-02-08     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA. Horwitz@virginia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion / physiology
Cell Adhesion Molecules / history*,  physiology
Extracellular Matrix Proteins / history,  physiology
History, 20th Century
History, 21st Century
Humans
Membrane Proteins / history,  physiology
Mice
Grant Support
ID/Acronym/Agency:
R01 GM023244/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Extracellular Matrix Proteins; 0/Membrane Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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