| The origins of the molecular era of adhesion research. | |
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MedLine Citation:
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PMID: 23151664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recognition of the importance of cell adhesion grew steadily during the twentieth century as it promised answers to fundamental questions in diverse fields that included cell biology, developmental biology, tumorigenesis, immunology and neurobiology. However, the route towards a better understanding of its molecular basis was long and difficult, with many false starts. Major progress was made in the late 1970s to late 1980s with the identification of the major families of adhesion molecules, including integrins and cadherins. This in turn set the stage for the explosive growth in adhesion research over the past 25 years. |
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Authors:
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Alan Rick Horwitz |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-15 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 13 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-23 Completed Date: 2013-02-08 Revised Date: 2013-04-19 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 805-11 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA. Horwitz@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / physiology Cell Adhesion Molecules / history*, physiology Extracellular Matrix Proteins / history, physiology History, 20th Century History, 21st Century Humans Membrane Proteins / history, physiology Mice |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM023244/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Extracellular Matrix Proteins; 0/Membrane Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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