Document Detail

The origin of the protein synthesis mechanism.
MedLine Citation:
PMID:  597595     Owner:  NLM     Status:  MEDLINE    
The origin and development of the protein synthesis mechanism is considered in four successive steps. The genetic code is supposed to be controlled by the relative amount (availability) of various amino acids and nucleotides on the one hand, and utility on each amino acid in the polypeptide. on the other hand. Thus, more simple (inutile) and abundant amino acids tended to correspond to codons which were rich in the less frequent base species, G and C. Features of primitive tRNA in the discrimination of amino acid are discussed. Primitive tRNA is proposed to have a discriminator site for amino acid and, separated from it, an anticodon site for interaction with nucleotides. A hypothetical course of subdivision of various nucleic acid species is proposed. In the scheme, mRNA and ribosomal RNA (rRNA) were derived from more primitive insoluble RNA. DNA appeared in the late, not first, step of the development. Several other aspects of evolutionary development of the whole protein synthesis mechanism, e.g., role of the discriminator site on primitive tRNA, modification and subdivision of code catalogue into a more precise specification of amino acids, and possible primordial interactions between tRNA and tRNA-binding sites on insoluble rRNA, are discussed.
M Ishigami; K Nagano; N Tonotsuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bio Systems     Volume:  9     ISSN:  0303-2647     ISO Abbreviation:  BioSystems     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  0430773     Medline TA:  Biosystems     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-43     Citation Subset:  IM; S    
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MeSH Terms
Amino Acyl-tRNA Synthetases / metabolism
Base Sequence
DNA / metabolism
Models, Biological
Peptide Biosynthesis
Protein Biosynthesis*
RNA / metabolism
RNA, Messenger / metabolism
RNA, Ribosomal / metabolism
RNA, Transfer / metabolism
Templates, Genetic
Transfer RNA Aminoacylation
Reg. No./Substance:
0/Codon; 0/RNA, Messenger; 0/RNA, Ribosomal; 63231-63-0/RNA; 9007-49-2/DNA; 9014-25-9/RNA, Transfer; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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