Document Detail


On the origin of the liver.
MedLine Citation:
PMID:  22105167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While it has been well established that the fetal liver originates from foregut endoderm, the identity of the mechanisms that maintain liver mass under both basal and injury conditions remains controversial. Dramatically different models have been proposed based on the experimental design employed. In this issue of the JCI, Malato and colleagues report their elegant new model for genetic lineage tracing of mature mouse hepatocytes using an adenoassociated virus-driven Cre recombinase. They show convincingly that maintenance of liver mass during normal turnover or in response to mild injury is achieved by mature hepatocytes, rather than cholangiocytes or specialized progenitor cells, as has been suggested by others.
Authors:
Joshua R Friedman; Klaus H Kaestner
Related Documents :
9501507 - Predicting acute toxicity (lc50) of benzene derivatives using theoretical molecular des...
20858057 - Quantitative structure-activity relationship analysis of 4(3h)-quinazolone derivatives ...
22231807 - Animal models of self-injurious behaviour: an overview.
19937857 - Predictions of chromatographic retention indices of alkylphenols with support vector ma...
3565597 - Statistical and graphical evaluation of erythrocyte volume distributions.
24621377 - The evolution of floral deception in epipactis veratrifolia (orchidaceae): from indirec...
Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-21
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  121     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-01-31     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4630-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Hepatocytes / cytology*
Homeostasis / physiology*
Liver / physiology*
Liver Regeneration / physiology*
Grant Support
ID/Acronym/Agency:
P01 DK049210/DK/NIDDK NIH HHS; R01 DK079881/DK/NIDDK NIH HHS; R01 DK079881/DK/NIDDK NIH HHS
Comments/Corrections
Comment On:
J Clin Invest. 2011 Dec;121(12):4850-60   [PMID:  22105172 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Another VCP interactor: NF is enough.
Next Document:  In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafi...