| The origin and identity of embryonic stem cells. | |
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MedLine Citation:
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PMID: 21138972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Embryonic stem (ES) cells are used extensively in biomedical research and as a model with which to study early mammalian development, but their exact origin has been subject to much debate. They are routinely derived from pre-implantation embryos, but it has been suggested that the cells that give rise to ES cells might arise from epiblast cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to ES cell status via the PGC lineage. Based on recent findings, we propose here that ES cells can be derived directly from early epiblast cells and that ES cells might arise via two different routes that are dictated by their culture conditions. |
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Authors:
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Jennifer Nichols; Austin Smith |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 138 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
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Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. jn270@cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryo Implantation / physiology Embryo, Mammalian / cytology Embryonic Stem Cells / cytology*, metabolism Germ Layers / cytology, metabolism Humans Models, Biological Pluripotent Stem Cells / cytology, metabolism |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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