Document Detail

The origin and identity of embryonic stem cells.
MedLine Citation:
PMID:  21138972     Owner:  NLM     Status:  MEDLINE    
Embryonic stem (ES) cells are used extensively in biomedical research and as a model with which to study early mammalian development, but their exact origin has been subject to much debate. They are routinely derived from pre-implantation embryos, but it has been suggested that the cells that give rise to ES cells might arise from epiblast cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to ES cell status via the PGC lineage. Based on recent findings, we propose here that ES cells can be derived directly from early epiblast cells and that ES cells might arise via two different routes that are dictated by their culture conditions.
Jennifer Nichols; Austin Smith
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-01-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
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MeSH Terms
Embryo Implantation / physiology
Embryo, Mammalian / cytology
Embryonic Stem Cells / cytology*,  metabolism
Germ Layers / cytology,  metabolism
Models, Biological
Pluripotent Stem Cells / cytology,  metabolism
Grant Support
G0800784//Medical Research Council; G1100526//Medical Research Council

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