Document Detail

On the origin of the genetic code.
MedLine Citation:
PMID:  7523187     Owner:  NLM     Status:  MEDLINE    
A series of stages in the evolution of the genetic code is postulated, representing a chain of logical steps that leads to the present-day code. The stages described are based on translation machinery between the RNA world and that of amino acids, a model that consists of an RNA assembler strand along which RNA hairpin molecules are lined up, forming a picket-fence-like aggregate. Each hairpin carries an amino acid at the bottom of one of its legs, and the mutual proximity of amino acids achieved in this way facilitates their linkage into oligopeptides, in a sequence governed by the nucleotide sequence along the assembler strand, the code. The order in which amino acids are introduced into the code is in the approximate order of their availability, tempered by polarity and structural considerations.
H Kuhn; J Waser
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  FEBS letters     Volume:  352     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-07     Completed Date:  1994-11-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM; S    
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
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MeSH Terms
Amino Acid Sequence
Base Sequence
DNA Replication
Genetic Code*
Models, Genetic*
Molecular Sequence Data
Nucleic Acid Conformation*
RNA / chemistry,  genetics*
Reading Frames
Templates, Genetic
Reg. No./Substance:
0/Codon; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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