| The origin of citrulline-containing proteins in the hair follicle and the chemical nature of trichohyalin, an intracellular precursor. | |
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MedLine Citation:
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PMID: 410454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present studies have demonstrated that the medulla and inner root sheath cells develop within their cytoplasm a protein that is unique in composition and is present in the trichohyalin granules. The protein is rich in arginine residues, some of which undergo a side-chain conversion in situ into citrulline residues. An unusual Ca2+-dependent enzyme activity distinguishable from cross-linking transamidase has been detected in the hair follicle and will act in vitro on trichohyalin protein as the natural substrate. The conversion in vivo must occur during the time that the medullary and inner root sheath cells move up the follicle and their cytoplasm fills with cross-linked protein containing citrulline. The function of citrulline in these proteins is not understood but its formation is a major process during hair growth. |
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Authors:
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G E Rogers; H W Harding; I J Llewellyn-Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 495 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 159-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis Animals Citrulline* Fluorescent Antibody Technique Guinea Pigs Hair / analysis*, ultrastructure Immunodiffusion Immunoelectrophoresis Male Protein Precursors* Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Protein Precursors; 0/Proteins; 372-75-8/Citrulline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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