Document Detail

The origin of ciliated cell cysts of the anterior pituitary. An experimental study in the rat.
MedLine Citation:
PMID:  2446416     Owner:  NLM     Status:  MEDLINE    
Rats were decapitated and the heads were stored at 4 degrees C for 24 h. The anterior pituitaries were then removed and incubated for 5 days. On the 1st, 3rd and 5th days of incubation, explants were studied by electron microscopy and immunohistochemistry using antiserum against S-100 protein. In the explant many granulated cells underwent necrosis; folliculo-stellate (FS) cells formed many cyst-like structures (CLSs) and became squamous epithelioid cells (CLS-forming cells). After incubation for 5 days the explants were isotransplanted under the renal capsules of male rats in order to observe morphological changes in the CLSs. Immediately after transplantation, the CLSs were encircled by a basement membrane, but from the 8th to 14th day, ciliation occurred in CLS-forming cells and "ciliated cell cysts" were formed. The ciliated cells were immunostained with antiserum against S-100 protein. The present study suggests that FS cells are related to CLS formation and have the potential to trans-differentiate to ciliated cells.
G Gon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  412     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-13     Completed Date:  1988-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Department of Anatomy, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Cell Transformation, Neoplastic / metabolism,  pathology*
Cilia / metabolism,  pathology
Immune Sera / pharmacology
Microscopy, Electron
Neoplasm Transplantation
Organ Culture Techniques
Pituitary Gland, Anterior / metabolism,  pathology*,  transplantation
Pituitary Neoplasms / etiology,  metabolism,  pathology*
Rats, Inbred Strains
S100 Proteins / immunology
Staining and Labeling / methods
Time Factors
Reg. No./Substance:
0/Immune Sera; 0/S100 Proteins

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