Document Detail

The organization of two new cortical interneuronal circuits.
MedLine Citation:
PMID:  23313910     Owner:  NLM     Status:  MEDLINE    
Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) interneurons and L5 pyramidal neurons in the rat neocortex. L1 single-bouquet cells (SBCs) preferentially formed unidirectional inhibitory connections on L2/3 interneurons that inhibited the entire dendritic-somato-axonal axis of ∼1% of L5 pyramidal neurons located in the same column. In contrast, L1 elongated neurogliaform cells (ENGCs) frequently formed mutual inhibitory and electric connections with L2/3 interneurons, and these L1-3 interneurons inhibited the distal apical dendrite of >60% of L5 pyramidal neurons across multiple columns. Functionally, SBC→L2/3 interneuron→L5 pyramidal neuronal circuits disinhibited and ENGC↔L2/3 interneuron→L5 pyramidal neuronal circuits inhibited the initiation of dendritic complex spikes in L5 pyramidal neurons. As dendritic complex spikes can serve coincidence detection, these cortical interneuronal circuits may be essential for salience selection.
Xiaolong Jiang; Guangfu Wang; Alice J Lee; Ruth L Stornetta; J Julius Zhu
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-13
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
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MeSH Terms
Age Factors
Analysis of Variance
Cerebral Cortex / cytology*
Electron Microscope Tomography
Interneurons / classification*,  physiology*,  ultrastructure
Membrane Potentials / physiology
Nerve Net / physiology*
Neural Inhibition / physiology
Neural Pathways / physiology*
Patch-Clamp Techniques
Rats, Sprague-Dawley
Vibrissae / innervation
Grant Support
Comment In:
Nat Neurosci. 2013 Feb;16(2):114-5   [PMID:  23354381 ]
Erratum In:
Nat Neurosci. 2013 Dec;16(12):1908

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