Document Detail

The orexin neuropeptide system: physical activity and hypothalamic function throughout the aging process.
MedLine Citation:
PMID:  25408639     Owner:  NLM     Status:  Publisher    
There is a rising medical need for novel therapeutic targets of physical activity. Physical activity spans from spontaneous, low intensity movements to voluntary, high-intensity exercise. Regulation of spontaneous and voluntary movement is distributed over many brain areas and neural substrates, but the specific cellular and molecular mechanisms responsible for mediating overall activity levels are not well understood. The hypothalamus plays a central role in the control of physical activity, which is executed through coordination of multiple signaling systems, including the orexin neuropeptides. Orexin producing neurons integrate physiological and metabolic information to coordinate multiple behavioral states and modulate physical activity in response to the environment. This review is organized around three questions: (1) How do orexin peptides modulate physical activity? (2) What are the effects of aging and lifestyle choices on physical activity? (3) What are the effects of aging on hypothalamic function and the orexin peptides? Discussion of these questions will provide a summary of the current state of knowledge regarding hypothalamic orexin regulation of physical activity during aging and provide a platform on which to develop improved clinical outcomes in age-associated obesity and metabolic syndromes.
Anastasia N Zink; Claudio Esteban Perez-Leighton; Catherine M Kotz
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Publication Detail:
Type:  REVIEW     Date:  2014-11-04
Journal Detail:
Title:  Frontiers in systems neuroscience     Volume:  8     ISSN:  1662-5137     ISO Abbreviation:  Front Syst Neurosci     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-19     Completed Date:  -     Revised Date:  2014-11-20    
Medline Journal Info:
Nlm Unique ID:  101477946     Medline TA:  Front Syst Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  211     Citation Subset:  -    
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