Document Detail

The ordinary light microscope: an appropriate tool for provisional detection and identification of crystals in synovial fluid.
MedLine Citation:
PMID:  2559666     Owner:  NLM     Status:  MEDLINE    
To determine if the ordinary light microscope is a useful tool in the detection and identification of crystals in synovial fluid 63 fluids (13 with monosodium urate (MSU), 14 with calcium pyrophosphate dihydrate (CPPD), one with both types of crystal, and 35 without crystals) were examined blindly by two observers, first with an ordinary light microscope, then with a polarising light microscope. Tentative identification of the crystals by their shape was attempted. The sensitivity of the ordinary light microscope for the detection of crystals was 96.2% and 100%, with specificity of 100% and 97.1% for observers 1 and 2, both with respect to the polarising light microscope. The concordance between observers for the ordinary light microscope was chi = 0.90 (0.897, 0.902) and for the polarising light microscope chi = 0.96 (0.958, 0.961). The specificity for identification of MSU and CPPD crystals by their shape with respect to the polarising light microscope was 92.3% and 85.7% for observers 1 and 2. When a polarising light microscope is not available examination of synovial fluid by an ordinary light microscope may allow a provisional diagnosis; definitive identification of the crystals requires a polarising light microscope.
E Pascual; J Tovar; M T Ruiz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  48     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-23     Completed Date:  1990-02-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  983-5     Citation Subset:  IM    
Rheumatology Section, Hospital de Alicante, Spain.
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MeSH Terms
Diphosphates / analysis
Microscopy / instrumentation*
Microscopy, Polarization / instrumentation
Synovial Fluid / analysis*
Uric Acid / analysis
Reg. No./Substance:
0/Diphosphates; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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