| The order of PNA-FISH-detected chromosomal telomere lengths in human T-cells is rather stable, even under the influence of strong mutagens. | |
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MedLine Citation:
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PMID: 16211269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nucleo-protein structure of an intact telomere protects each chromosome from being recognized as a break and subsequently being degraded. The DNA component of this structure, the telomeric repeats, undergo attrition with every cell division, as well as in response to endogenous events, like oxidative stress. Exposure to exogenous damage promotes this process and leads to growth arrest, apoptosis and eventually to malignant transformation. It was thought that the shortest chromosome ends in humans are the most susceptible ones to become dysfunctional telomeres, and have therefore an important role in cell death and cancer. Here, we show that a stable hierarchy exists in the form of a telomere length profile of the whole human karyotype. This rank order is conserved between different human cell types and individuals, is maintained throughout a lifetime, and seems to be genetically determined. As a particular feature, this telomere length profile differs only marginally when normal human cell cultures and malignant transformed cells are compared. The profile is moreover stable when these different human cells are exposed to mutagens such as bleomycin or mitomycin C. From these findings, the question arises if also the stably long telomeres have a basic biological function. |
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Authors:
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U Wick; E Gebhart |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 16 ISSN: 1107-3756 ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-07 Completed Date: 2005-12-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 951-7 Citation Subset: IM |
Affiliation:
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Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bleomycin
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toxicity Cell Line, Tumor Chromosomes, Human / drug effects, genetics Humans In Situ Hybridization, Fluorescence Leukemia-Lymphoma, Adult T-Cell Mitomycin / toxicity Mutagens / toxicity* Nucleic Acid Probes Nucleoproteins / metabolism Peptide Nucleic Acids / chemistry T-Lymphocytes / chemistry, drug effects Telomere / drug effects*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Mutagens; 0/Nucleic Acid Probes; 0/Nucleoproteins; 0/Peptide Nucleic Acids; 11056-06-7/Bleomycin; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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