Document Detail

The orbitofrontal cortex and response selection.
MedLine Citation:
PMID:  22145872     Owner:  NLM     Status:  MEDLINE    
Orbitofrontal cortex (OFC) function is often characterized in terms of stimulus-reward mapping; however, more recent evidence suggests that the OFC may play a role in selecting and representing extended actions. First, previously encoded reward associations in the OFC could be used to inform responding in novel but similar situations. Second, when evaluated in tasks requiring the animal to perform extended actions, response selective activity can be recorded in the OFC. Finally, the interaction between the OFC and hippocampus illustrates OFC's role in response selection. The OFC may facilitate reward-guided memory retrieval by selecting the memories most relevant to achieve a goal. This model for OFC function places it within the hierarchy of increasingly complex action representations that support decision making.
James J Young; Matthew L Shapiro
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1239     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  2012-02-13     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
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MeSH Terms
Behavior, Animal
Brain Mapping*
Decision Making
Frontal Lobe / physiology*
Hippocampus / physiology
Models, Psychological
Neurons / physiology*
Physiology, Comparative / methods
Reversal Learning

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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