Document Detail


An oral two-generation reproductive toxicity study of S-111-S-WB in rats.
MedLine Citation:
PMID:  18022344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
S-111-S-WB (CAS No. 72968-38-8), a mixture of perfluoro fatty acid ammonium salts, was administered daily via oral gavage to 30 Crl:CD(SD) rats/sex/group at 0.025, 0.125 and 0.6mg/(kgday) over two generations to assess potential reproductive toxicity. Reproductive performance, mean litter size, pup survival and pup weights were unaffected. Lower mean body weights were observed in 0.6mg/(kgday) group F(0) and F(1) males. Higher liver weights, correlating to hepatocellular hypertrophy in the 0.6mg/kg group, were noted for parental males in the 0.125 and 0.6mg/(kgday) groups, parental females in the 0.6mg/(kgday) group and F(1) pups in the 0.125 and 0.6mg/(kgday) groups. Higher kidney weights, correlating to renal tubule hypertrophy in the 0.6mg/kg group, were observed for parental males and females in the 0.125 and 0.6mg/(kgday) groups. Systemic exposure (measured only in females) to total S-111-S-WB was proportional to dose following 9 weeks of daily administration on the gestation day 19. Total S-111-S-WB concentration in the serum of male and female pups was 1.2-1.4-fold higher than in the dams 2h following administration to the dams on lactation day 13. A dosage level of 0.6mg/(kgday) was considered to be the no-observed-adverse-effect level (NOAEL) for reproductive function. A dosage level of less than 0.025mg/(kgday) was considered to be the NOAEL for F(0) and F(1) parental systemic toxicity based on microscopic hepatic findings in the males of all test article groups, and a dosage level of 0.025mg/(kgday) was considered to be the NOAEL for neonatal toxicity based on higher liver weights in the F(1) and F(2) pups at 0.125mg/(kgday) and higher.
Authors:
Donald G Stump; Joseph F Holson; Sandra R Murphy; Craig H Farr; Bruno Schmit; Motoki Shinohara
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Publication Detail:
Type:  Journal Article     Date:  2007-10-07
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  25     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-20     Citation Subset:  IM    
Affiliation:
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA. dstump@wilresearch.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Animals, Newborn
Birth Weight / drug effects
Body Weight / drug effects
Breeding
Dose-Response Relationship, Drug
Eating / drug effects
Fatty Acids / administration & dosage,  metabolism,  toxicity*
Female
Growth and Development / drug effects
Hydrocarbons, Fluorinated / administration & dosage,  metabolism,  toxicity*
Kidney / drug effects,  pathology
Lactation
Litter Size / drug effects
Liver / drug effects,  pathology
Male
No-Observed-Adverse-Effect Level
Organ Size
Rats
Rats, Sprague-Dawley
Reproduction / drug effects*
Spermatogenesis / drug effects
Surface-Active Agents / administration & dosage,  metabolism,  toxicity*
Time Factors
Toxicity Tests, Chronic
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Hydrocarbons, Fluorinated; 0/S-111-S-WB; 0/Surface-Active Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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