Document Detail

The oral mucosa in paucibacillary leprosy: a clinical and histopathological study.
MedLine Citation:
PMID:  17223587     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Involvement of the oral mucosa can occur in lepromatous leprosy; however, lesions in the oral mucosa of paucibacillary patients have not been previously observed. OBJECTIVE: The objective of this study is to determine whether clinical and subclinical lesions exist in oral mucosa in nontreated paucibacillary leprosy patients, using clinical and histopathological examination. MATERIALS AND METHODS: A clinical and histopathological study involving 30 untreated paucibacillary leprosy patients was conducted. All patients underwent biopsies of the buccal mucosa, soft palate, and tongue. When acid-fast bacilli in association with inflammatory infiltrate, granulomatous or not, were encountered, it was considered "specific" involvement of the oral mucosa; and "nonspecific" involvement when the bacilli were not encountered. RESULTS: Eight nonspecific chronic inflammatory reactions and 1 granulomatous inflammatory process without acid-fast bacilli were detected. CONCLUSIONS: Paucibacillary leprosy patients do not exhibit specific, clinical or subclinical, involvement in the oral mucosa; nonspecific alterations occur even in the absence of signs and symptoms.
Marilda Aparecida Milanez Morgado de Abreu; Maurício Mota de Avelar Alchorne; Nilceo Schwery Michalany; Luc Louis Maurice Weckx; Dalva Regina Neto Pimentel; Cleonice Hitomi Watashi Hirata
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Publication Detail:
Type:  Journal Article     Date:  2007-01-12
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  103     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48-52     Citation Subset:  D; IM    
Department of Dermatology, Division of Stomatology, Federal University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Leprosy / microbiology*,  pathology
Middle Aged
Mouth Diseases / microbiology*,  pathology
Mouth Mucosa / microbiology*,  pathology
Mycobacterium leprae / isolation & purification

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