Document Detail


The oral mucosa immune environment and oral transmission of HIV/SIV.
MedLine Citation:
PMID:  23772613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The global spread of human immunodeficiency virus (HIV) is dependent on the ability of this virus to efficiently cross from one host to the next by traversing a mucosal membrane. Unraveling how mucosal exposure of HIV results in systemic infection is critical for the development of effective therapeutic strategies. This review focuses on understanding the immune events associated with the oral route of transmission (via breastfeeding or sexual oral intercourse), which occurs across the oral and/or gastrointestinal mucosa. Studies in both humans and simian immunodeficiency virus (SIV) monkey models have identified viral changes and immune events associated with oral HIV/SIV exposure. This review covers our current knowledge of HIV oral transmission in both infants and adults, the use of SIV models in understanding early immune events, oral immune factors that modulate HIV/SIV susceptibility (including mucosal inflammation), and interventions that may impact oral HIV transmission rates. Understanding the factors that influence oral HIV transmission will provide the foundation for developing immune therapeutic and vaccine strategies that can protect both infants and adults from oral HIV transmission.
Authors:
Lianna F Wood; Ann Chahroudi; Hui-Ling Chen; Heather B Jaspan; Donald L Sodora
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  254     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-01-24     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-53     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Adult
Age Factors
Animals
Disease Models, Animal
Disease Susceptibility / immunology
HIV / immunology*
HIV Infections / immunology*,  transmission*
Host-Pathogen Interactions
Humans
Immunity, Innate
Infant
Infant, Newborn
Inflammation / immunology
Mouth Mucosa / immunology*,  virology*
Simian Acquired Immunodeficiency Syndrome / immunology*,  transmission*
Simian immunodeficiency virus / immunology*
Grant Support
ID/Acronym/Agency:
AI027757/AI/NIAID NIH HHS; F30 ES022535/ES/NIEHS NIH HHS; F30 ES022535/ES/NIEHS NIH HHS; K08 HD069201/HD/NICHD NIH HHS; K08 HD069201/HD/NICHD NIH HHS; P30 AI027757/AI/NIAID NIH HHS; P30 AI050409/AI/NIAID NIH HHS; R01 DE012926/DE/NIDCR NIH HHS; R01 DE017541/DE/NIDCR NIH HHS; R01 DE017541/DE/NIDCR NIH HHS; T32 GM007266/GM/NIGMS NIH HHS
Comments/Corrections

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