| The oral mucosa as a therapeutic target for xerostomia. | |
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MedLine Citation:
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PMID: 19193197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune disorders, medical interventions, and aging are all known to be associated with salivary gland hypofunction, which results in the uncomfortable feeling of dry mouth (xerostomia) and significantly diminished oral health. The current therapeutic regimen includes increasing oral hydration using over-the-counter oral comfort agents and the use of systemic cholinergic drugs to stimulate salivary output. However, these approaches produce very transient relief or are associated with uncomfortable side-effects. Thus, new treatments that provide long-lasting relief from discomfort and improve oral health with minimal side-effects would benefit the therapy of this disease. The processes that mediate fluid loss from the oral cavity, such as the absorption of fluid from the oral mucosa, represent novel therapeutic targets for xerostomia. Preventing fluid absorption from the oral cavity is predicted to improve oral hydration and alleviate the clinical symptoms and discomfort associated with dry mouth. Furthermore, therapeutic strategies that prevent fluid absorption should complement current approaches that increase salivary output. This review discusses the current understanding of oral fluid balance and how these processes may be manipulated to provide relief for those suffering from dry mouth. |
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Authors:
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W R Thelin; M T Brennan; P B Lockhart; M L Singh; P C Fox; A S Papas; R C Boucher |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Oral diseases Volume: 14 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-02-05 Completed Date: 2009-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 683-9 Citation Subset: D |
Affiliation:
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Parion Sciences, Durham, NC, USA. bthelin@parion.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Body Water / drug effects, metabolism Humans Ion Transport / drug effects Mouth Mucosa / drug effects*, metabolism Saliva / drug effects, secretion Secretory Rate / drug effects Water / metabolism Water-Electrolyte Balance / drug effects Xerostomia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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