Document Detail

The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients.
MedLine Citation:
PMID:  11271629     Owner:  NLM     Status:  MEDLINE    
The oral manifestations of chronic graft-versus-host disease (cGVHD) in eight allogeneic bone marrow transplant (BMT) paediatric recipients were studied clinically, and lip biopsies were performed in seven of them. A prominent lichenoid reaction was observed in four patients, two with accompanying ulceration. Superficial mucoceles were present in three children. Clinically obvious xerostomia was seen in seven patients. Lip biopsies were positive and correlated with the clinical manifestations. Both clinical and histological findings confirmed the diagnosis of cGVHD. In three additional children, with systemic manifestations indicating cGVHD, the oral mucosa was clinically and histologically normal, and the systemic manifestations were, thus, attributed to drug reactions. The above findings indicate the high value of oral examination in diagnosing or confirming paediatric cGVHD. Superficial mucoceles, reported for the first time in paediatric recipients, seem to be important in the early diagnosis of cGVHD.
O Nicolatou-Galitis; V Kitra; C Van Vliet-Constantinidou; J Peristeri; E Goussetis; D Petropoulos; S Grafakos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  30     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  D; IM    
Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Greece.
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MeSH Terms
Bone Marrow Transplantation / adverse effects*
Chronic Disease
Graft vs Host Disease / complications*,  diagnosis,  etiology
Lichen Planus, Oral / etiology
Lip / pathology
Mouth Diseases / etiology*
Mouth Mucosa / pathology*
Mucocele / etiology
Xerostomia / etiology

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