| MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature. | |
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MedLine Citation:
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PMID: 11505267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although liposarcoma is one of the most common soft tissue sarcomas, its location in the oral cavity is very rare. To our knowledge, only 43 cases of liposarcoma originating in the oral tissues have been reported in the English-language literature. In this article, we report a case of well-differentiated liposarcoma affecting the cheek of a 28-year-old man and review the oral liposarcoma literature. Immunohistochemical analysis of the tumor revealed an MDM2+/CDK4+/p53+ immunophenotype that is consistent with the immunohistochemical profile of well-differentiated liposarcoma originating in other areas of the body. Quantitative polymerase chain reaction analysis of the DNA levels of the MDM2 (human homologue of the murine double-minute type 2), CDK4 (cyclin-dependent kinase 4), and SAS (sarcoma amplified sequence), genes was performed, revealing only SAS gene amplification. The possibility of misdiagnosis of oral liposarcoma because of its sometimes inconspicuous clinical and microscopic features is emphasized. Careful pathologic examination of liposarcoma is essential for discrimination from benign adipose tissue neoplasms and for precise histologic classification, both of major prognostic significance. Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed. |
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Authors:
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N G Nikitakis; M A Lopes; A E Pazoki; R A Ord; J J Sauk |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 92 ISSN: 1079-2104 ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-15 Completed Date: 2001-11-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 194-201 Citation Subset: D; IM |
Affiliation:
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Oral and Maxi;;ofacial Pathology, Dental School, University of Maryland, Baltimore 21201-1586, USA. nin001@dental.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases / genetics* DNA, Neoplasm / genetics Diagnosis, Differential Gene Expression Regulation, Neoplastic / genetics Genes, p53 / genetics* Humans Immunohistochemistry Immunophenotyping Liposarcoma / genetics*, pathology Male Membrane Proteins / genetics Mouth Neoplasms / genetics*, pathology Neoplasm Proteins / genetics* Nuclear Proteins / genetics* Polymerase Chain Reaction Prognosis Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins c-mdm2 |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Membrane Proteins; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/TSPAN31 protein, human; EC 2.7.1.37/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 6.3.2.19/MDM2 protein, human; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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