Document Detail

An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise.
MedLine Citation:
PMID:  10658002     Owner:  NLM     Status:  MEDLINE    
This study was designed to determine the response of muscle protein to the bolus ingestion of a drink containing essential amino acids and carbohydrate after resistance exercise. Six subjects (3 men, 3 women) randomly consumed a treatment drink (6 g essential amino acids, 35 g sucrose) or a flavored placebo drink 1 h or 3 h after a bout of resistance exercise on two separate occasions. We used a three-compartment model for determination of leg muscle protein kinetics. The model involves the infusion of ring-(2)H(5)-phenylalanine, femoral arterial and venous blood sampling, and muscle biopsies. Phenylalanine net balance and muscle protein synthesis were significantly increased above the predrink and corresponding placebo value (P < 0.05) when the drink was taken 1 or 3 h after exercise but not when the placebo was ingested at 1 or 3 h. The response to the amino acid-carbohydrate drink produced similar anabolic responses at 1 and 3 h. Muscle protein breakdown did not change in response to the drink. We conclude that essential amino acids with carbohydrates stimulate muscle protein anabolism by increasing muscle protein synthesis when ingested 1 or 3 h after resistance exercise.
B B Rasmussen; K D Tipton; S L Miller; S E Wolf; R R Wolfe
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-03     Completed Date:  2000-03-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  386-92     Citation Subset:  IM; S    
Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Institute, Galveston, Texas 77550, USA.
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MeSH Terms
Administration, Oral
Amino Acids, Essential / administration & dosage,  pharmacology*
Analysis of Variance
Carbohydrates / administration & dosage,  pharmacology*
Dietary Supplements
Exercise / physiology*
Femoral Artery / drug effects,  metabolism
Femoral Vein / drug effects,  metabolism
Insulin / blood
Leg / blood supply
Muscle Proteins / drug effects*,  metabolism
Phenylalanine / drug effects,  metabolism
Regional Blood Flow / drug effects
Time Factors
Grant Support
38010//PHS HHS; M01RR00073/RR/NCRR NIH HHS
Reg. No./Substance:
0/Amino Acids, Essential; 0/Carbohydrates; 0/Insulin; 0/Muscle Proteins; 63-91-2/Phenylalanine

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