Document Detail

The oral contraceptive containing 30 microg of ethinylestradiol plus 3 mg of drospirenone is able to antagonize the increase of extracellular water occurring in healthy young women during the luteal phase of the menstrual cycle: an observational study.
MedLine Citation:
PMID:  17303489     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This nonrandomized study aimed to evaluate body weight and composition during the menstrual cycle and during oral contraception with 30 microg of ethinylestradiol plus 3 mg of drospirenone (EE+DRSP). DESIGN: Multifrequency bioelectrical impedance analysis was carried out in 38 normally cycling women (mean age, 25.5 years) at baseline during the follicular phase (FP) and the luteal phase (LP) of the menstrual cycle and after three and six cycles of EE+DRSP to evaluate total body water (TBW), intracellular water (ICW), extracellular water (ECW), fat mass and fat-free mass. Body weight, waist-to-hip ratio, blood pressure and the plasma concentrations of electrolytes were also determined at each visit. RESULTS: TBW and ECW increased in the LP. During EE+DRSP, TBW and ECW were significantly lower than in the LP but similar to the values measured in the FP. No significant variations in ICW or in the other parameters were observed. CONCLUSION: EE+DRSP maintains the same concentrations in TBW and ECW observed in the FP. This effect is likely due to the antimineralocorticoid activity of DRSP, which counteracts the water retention elicited by estrogen.
Franca Fruzzetti; Stefano Lello; Veronica Lazzarini; Stefania Fratta; Marisa Orrù; Roberto Sorge; Luigi Minerba; Cabiria Ricci; Andrea Riccardo Genazzani; Gian Benedetto Melis; Anna Maria Paoletti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-01-16
Journal Detail:
Title:  Contraception     Volume:  75     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Pisa, 56100 Pisa, Italy.
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MeSH Terms
Aldosterone Antagonists / pharmacology
Androstenes / pharmacology*
Body Composition / drug effects*,  physiology
Body Water / metabolism*
Body Weight / drug effects
Contraceptives, Oral, Combined
Electric Impedance
Estrogens / pharmacology
Ethinyl Estradiol / pharmacology*
Extracellular Fluid / drug effects*
Intracellular Fluid / metabolism
Luteal Phase / metabolism
Mineralocorticoids / antagonists & inhibitors*
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Androstenes; 0/Contraceptives, Oral, Combined; 0/Estrogens; 0/Mineralocorticoids; 57-63-6/Ethinyl Estradiol; 67392-87-4/drospirenone

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