Document Detail


The oral allergy syndrome: improved diagnostic and treatment methods.
MedLine Citation:
PMID:  15864087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The aim of this article is to review recent clinical and molecular findings related to the oral allergy syndrome in order to define its relevance in the field of food allergy, describe current diagnostic approaches and discuss attempts to use specific immunotherapy for treatment. RECENT FINDINGS: New allergenic sources causing the oral allergy syndrome have been reported. Their allergenic molecules have been identified. In most of those studies oral allergy syndrome is reported as a clinical manifestation among more severe ones. Some of the molecules generally considered not to be at risk for severe reactions have been demonstrated to pose a threat for inducing generalized reactions. Some studies tried to assess the usefulness of immunotherapy with birch pollen extract by either subcutaneous or sublingual routes for the treatment of associated food allergies. In most of the cases, a well defined study design and a molecular approach at different study levels are lacking and thus the value of the obtained results is limited. To date, no final conclusion can be drawn on the basis of reported results. SUMMARY: The knowledge about the highly prevalent phenomenon of oral allergy syndrome is still incomplete, in respect to both, epidemiology and foods inducing symptoms. It is very important to reach consensus on several aspects of this food-induced allergic disease. Further studies are required to highlight whether immunotherapy using co-recognized inhalant allergens is an effective way of curative treatment, or if co-treatment with purified pollen-related food allergens will be required to obtain a long-lasting effect.
Authors:
Adriano Mari; Barbara K Ballmer-Weber; Stefan Vieths
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  5     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-07-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
Affiliation:
Allergy Unit, National Health Service, Rome, Italy. a.mari@panservice.it
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MeSH Terms
Descriptor/Qualifier:
Desensitization, Immunologic / methods
Food Hypersensitivity / diagnosis*,  epidemiology,  immunology,  therapy*
Humans
Mouth Mucosa / immunology*
Plant Proteins / immunology*
Chemical
Reg. No./Substance:
0/Plant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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