Document Detail

An optofluidic device for surface enhanced Raman spectroscopy.
MedLine Citation:
PMID:  17476383     Owner:  NLM     Status:  MEDLINE    
We have developed an optofluidic device that improves the sensitivity of surface enhanced Raman spectroscopy (SERS) when compared to other SERS approaches. This device has a pinched and step microchannel-nanochannel junction that can trap and assemble nanoparticles/target molecules into optically enhanced SERS active clusters by using capillary force. These SERS active clusters provide an electromagnetic enhancement factor of approximately 10(8). In addition, due to the continuous capillary flow that can transport nanoparticles/target molecules into the junction sites, the numbers of nanoparticles/target molecules and SERS active sites are increased. As a result, the detection limit of SERS for adenine molecules was better than 10 pM.
Miao Wang; Nan Jing; I-Hsien Chou; Gerard L Cote; Jun Kameoka
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Publication Detail:
Type:  Journal Article     Date:  2007-02-28
Journal Detail:
Title:  Lab on a chip     Volume:  7     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-08-15     Revised Date:  2008-03-13    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  630-2     Citation Subset:  IM    
Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843-3128, USA.
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MeSH Terms
Microfluidic Analytical Techniques / instrumentation*,  methods*
Spectrum Analysis, Raman / instrumentation*,  methods*
Surface Properties
Reg. No./Substance:
Erratum In:
Lab Chip. 2008 Feb;8(2):362

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