Document Detail

The option of Linac-based radiosurgery in a Gamma Knife radiosurgery center.
MedLine Citation:
PMID:  18617321     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Due to the fundamental differences in treatment delivery, linear-accelerator-based radiosurgery can be complementary to Gamma Knife (GK) for intracranial lesions. We reviewed the effect of adding GK to an existing linear accelerator (Linac)-based radiosurgery practice and analyzed case selections for the two modalities. PATIENTS AND METHODS: UC Davis Medical Center installed a Leksell Gamma Knife Model C in October 2003 to supplement an established Linac-based radiosurgery program. Radiosurgery indications for the 15 months before and after installation were compared. RESULTS: Radiosurgery cases expanded by twofold from 68 patients before GK installation to 139 after, with 106 treated by GK and 33 by Linac. Besides a major increase for trigeminal neuralgia and a general growth for acoustic neuroma, meningioma and brain metastases, case numbers for glioma and arteriovenous malformation (AVM) remained stable. Considering case selections for Linac, glioma decreased from 28 to 18%, while meningioma and metastases increased from 9 to 21% and 38-46%, respectively. The Linac patients receiving fractionated treatment also increased from 37 to 61%. CONCLUSIONS: While the majority of patients were treated with GK, a significant proportion was judged to be suited for Linac treatment. This latter group included particularly patients who benefit from fractionated therapy.
Robin L Stern; Julian R Perks; Conrad T Pappas; James E Boggan; Allan Y Chen
Publication Detail:
Type:  Journal Article     Date:  2008-07-09
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-12     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  968-72     Citation Subset:  IM    
Department of Radiation Oncology, University of California, Davis Health System, Sacramento, CA, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / secondary,  surgery*
Follow-Up Studies
Meningeal Neoplasms / pathology,  surgery*
Meningioma / pathology,  surgery*
Neuroma, Acoustic / pathology,  surgery
Oncology Service, Hospital / organization & administration
Particle Accelerators
Radiation Oncology / organization & administration
Radiosurgery / instrumentation,  methods*
Radiotherapy Planning, Computer-Assisted / methods
Radiotherapy, Intensity-Modulated / methods
Surgery Department, Hospital / organization & administration
Treatment Outcome
Trigeminal Neuralgia / pathology,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sparganosis presenting as radiculalgia at the conus medullaris.
Next Document:  Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis.