Document Detail

The optimum pneumoperitoneum pressure for laparoscopic surgery in the rat model. A detailed cardiorespiratory study.
MedLine Citation:
PMID:  9294272     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is increasing interest in the rat model of laparoscopic surgery. This study evaluates the cardiorespiratory effects of increasing CO2 pneumoperitoneum (PP) in the rat. METHODS: Nine Sprague-Dawley rats were subjected to CO2 PP at pressures of 2, 5, 10, and 15 mmHg or control (no PP) under anesthesia. Catheters were placed in the femoral artery and the jugular vein to measure heart rate (HR), blood pressure (MAP), and arterial pH, PCO2, PO2, and HCO3. A thermistor probe in the aortic arch measured cardiac output (CO) and blood temperature (BT). RESULTS: CO2 PP had no effect on CO, MAP, or BT at any pressure. CO2 PP greater than 5 mmHg caused significant bradycardia and CO2 PP greater than 10 mmHg caused significant respiratory acidosis. CONCLUSIONS: CO2 PP pressures above 10 mmHg in rat should be avoided when performing laparoscopic surgery in the rat model.
R Berguer; T Cornelius; M Dalton
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical endoscopy     Volume:  11     ISSN:  0930-2794     ISO Abbreviation:  Surg Endosc     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-09-30     Completed Date:  1997-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  915-8     Citation Subset:  IM    
Department of Surgery, University of California Davis, Sacramento, CA, USA.
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MeSH Terms
Analysis of Variance
Carbon Dioxide / administration & dosage
Cardiovascular Physiological Phenomena*
Disease Models, Animal
Laparoscopy / methods*
Pneumoperitoneum, Artificial / methods*
Rats, Sprague-Dawley
Reference Values
Survival Rate
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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