Document Detail


An optimal polymerization conditions for poly-human placenta hemoglobin with lower mean molecular weight.
MedLine Citation:
PMID:  23363417     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: To reduce the mean molecular weight [Formula: see text] and to increase the effective polymerization ratio (R(Eff)) of polymerized human placenta hemoglobin (PolyPHb). Methods: Three factors of GDA-PolyPHb process such as the approach of feeding GDA (F(GDA)), hemoglobin concentration ([Hb]) and the molar ratio of GDA, and hemoglobin(R(GDA:Hb)) were investigated. Finally, the expansion experiments were conducted with optimal conditions. Results: The data showed that the HBOCs with the R(Eff) of 67.35% and lower [Formula: see text] of 162.70 kDa were prepared by optimal conditions. Conclusion: Compared to original process, the optimal process greatly decreased the [Formula: see text] and increased the R(Eff.).
Authors:
Wentao Zhou; Lanzhen Zhao; Jinfeng Wang; Shen Li; Gang Chen; Jiaxin Liu; Chengmin Yang
Related Documents :
23468247 - A simple probabilistic model of multibody interactions in proteins.
24001817 - Optimisation of near-infrared reflectance model in measuring protein and amylose conten...
23209167 - How competition affects evolutionary rescue.
3398747 - Sequential analysis in a bayesian model of diastolic blood pressure measurement.
8054467 - Computer simulation of the free energy of peptides with the local states method: analog...
20330837 - What can we learn from statistics on acoustics?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-30
Journal Detail:
Title:  Artificial cells, nanomedicine, and biotechnology (Print)     Volume:  -     ISSN:  2169-141X     ISO Abbreviation:  Artif Cells Nanomed Biotechnol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101594777     Medline TA:  Artif Cells Nanomed Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Pharmaceutical Science & Technology, Tianjin University , Tianjin , P. R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A review of mometasone furoate / formoterol in the treatment of asthma.
Next Document:  UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of t...