Document Detail

An optimal polymerization conditions for poly-human placenta hemoglobin with lower mean molecular weight.
MedLine Citation:
PMID:  23363417     Owner:  NLM     Status:  Publisher    
Objectives: To reduce the mean molecular weight [Formula: see text] and to increase the effective polymerization ratio (R(Eff)) of polymerized human placenta hemoglobin (PolyPHb). Methods: Three factors of GDA-PolyPHb process such as the approach of feeding GDA (F(GDA)), hemoglobin concentration ([Hb]) and the molar ratio of GDA, and hemoglobin(R(GDA:Hb)) were investigated. Finally, the expansion experiments were conducted with optimal conditions. Results: The data showed that the HBOCs with the R(Eff) of 67.35% and lower [Formula: see text] of 162.70 kDa were prepared by optimal conditions. Conclusion: Compared to original process, the optimal process greatly decreased the [Formula: see text] and increased the R(Eff.).
Wentao Zhou; Lanzhen Zhao; Jinfeng Wang; Shen Li; Gang Chen; Jiaxin Liu; Chengmin Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-30
Journal Detail:
Title:  Artificial cells, nanomedicine, and biotechnology (Print)     Volume:  -     ISSN:  2169-141X     ISO Abbreviation:  Artif Cells Nanomed Biotechnol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101594777     Medline TA:  Artif Cells Nanomed Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Pharmaceutical Science & Technology, Tianjin University , Tianjin , P. R. China.
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