Document Detail


An optimal polymerization conditions for poly-human placenta hemoglobin with lower mean molecular weight.
MedLine Citation:
PMID:  23363417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To reduce the mean molecular weight [Formula: see text] and to increase the effective polymerization ratio (REff) of polymerized human placenta hemoglobin (PolyPHb).
METHODS: Three factors of GDA-PolyPHb process such as the approach of feeding GDA (FGDA), hemoglobin concentration ([Hb]) and the molar ratio of GDA, and hemoglobin(RGDA:Hb) were investigated. Finally, the expansion experiments were conducted with optimal conditions.
RESULTS: The data showed that the HBOCs with the REff of 67.35% and lower [Formula: see text] of 162.70 kDa were prepared by optimal conditions.
CONCLUSION: Compared to original process, the optimal process greatly decreased the [Formula: see text] and increased the REff.
Authors:
Wentao Zhou; Lanzhen Zhao; Jinfeng Wang; Shen Li; Gang Chen; Jiaxin Liu; Chengmin Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-30
Journal Detail:
Title:  Artificial cells, nanomedicine, and biotechnology     Volume:  41     ISSN:  2169-141X     ISO Abbreviation:  Artif Cells Nanomed Biotechnol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-27     Completed Date:  2014-04-22     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101594777     Medline TA:  Artif Cells Nanomed Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Transfusion*
Cell-Free System
Complementary Therapies*
Female
Glutaral / chemistry*
Hemoglobins / chemistry*,  metabolism
Humans
Molecular Weight
Placenta / metabolism
Polymerization*
Pregnancy
Chemical
Reg. No./Substance:
0/Hemoglobins; T3C89M417N/Glutaral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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