Document Detail


The optimal diagnostic workup for children with suspected food allergy.
MedLine Citation:
PMID:  21907896     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Food allergy is defined as an abnormal immunologic reaction to food proteins that causes an adverse clinical reaction. In addition to well-known acute allergic reactions and anaphylaxis triggered by immunoglobulin E antibody-mediated immune responses to food proteins, there is an increasing recognition of cell-mediated disorders such as eosinophilic esophagitis and food protein-induced enterocolitis syndrome. More than 90% of food allergies in childhood are caused by eight foods: cow's milk, hen's egg, soy, peanuts, tree nuts, wheat, fish, and shellfish. The diagnostic workup for a child with suspected food allergy includes a detailed medical history, physical examination, food allergy screening tests, and responses to an elimination diet and an oral food challenge. None of the screening tests, alone or in combination, can definitely diagnose or exclude a food allergy. Novel diagnostic methods including those that focus on immune responses to specific food proteins or epitopes of specific proteins are under active study. Unconventional diagnostic methods are increasingly used, but they lack scientific rationale, standardization, and reproducibility. In selected cases, such as eosinophilic esophageal gastroenteropathies or food protein-induced gastroesophageal reflux disease, invasive procedures are mandatory for an accurate diagnosis. Properly done, an oral food challenge is still the gold standard in the diagnostic workup. An incorrect diagnosis is likely to result in unnecessary dietary restrictions, which, if prolonged, may adversely affect the child's nutritional status and growth.
Authors:
Roberto Berni Canani; Mara Di Costanzo; Riccardo Troncone
Related Documents :
7611746 - Does exposure enhance liking for the chilli burn?
18680176 - Postprandial evolution in composition and characteristics of human duodenal fluids in d...
871276 - Food--fads and fallacies.
10978486 - The effects of variety and monotony on food acceptance and intake at a midday meal.
17126636 - Availability of weight-loss supplements: results of an audit of retail outlets in a sou...
21174866 - Food security in an era of economic volatility.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  27     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  983-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University of Naples "Federico II", Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monosomy1p36.3 and trisomy 19p13.3 in a child with periventricular nodular heterotopia.
Next Document:  Dietary fatty acid composition and metabolic syndrome in Tehranian adults.