| On the optimal defibrillation waveform--how to reconcile theory and experiment? | |
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MedLine Citation:
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PMID: 16916112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medical intervention by electrical current as applied to humans or animals may have tremendous therapeutic impact if delivered while being carefully controlled. Otherwise, the situation can be harmful in terms of injury or even become lethal. These consequences demand close inspection of all relevant biological and technical factors. Regarding methods to counter fibrillation of the heart substantial progress has been made, but defining a gold standard for the waveshape and energy delivery remains a serious challenge. The anticipated answer is not simply a range somewhere between a maximum and a minimum, but most likely an "intelligently" selected case-specific optimum, delicately positioned between effective and unsafe. Combining insight from theory with pertinent experimental findings may offer a clearer view on an unresolved issue that often points to a cross-road of life and death. |
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Authors:
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Vessela Tz Krasteva; Peter L M Kerkhof |
Publication Detail:
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Type: Comment; Letter |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 53 ISSN: 0018-9294 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-18 Completed Date: 2006-09-20 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1725-6; author reply 1726-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation Electric Countershock / methods* Evidence-Based Medicine / methods* Guinea Pigs Heart Conduction System / physiopathology* Heart Ventricles / physiopathology Male Models, Cardiovascular* Therapy, Computer-Assisted / methods* Treatment Outcome Ventricular Fibrillation / physiopathology*, therapy* |
| Comments/Corrections | |
Comment On:
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IEEE Trans Biomed Eng. 2006 Aug;53(8):1492-8
[PMID:
16916083
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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