Document Detail


An optical biosensor for rapid and label-free detection of cells.
MedLine Citation:
PMID:  16551065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a broadly applicable optical method for rapid and label-free detection of as few as 45 cells. In this method, bacterial cells are detected by measuring the amount of laser light transmitted through a small glass well functionalized with antibodies which specifically recognize and capture the cells. The described approach is simple, rapid, economical, and promising for portable and high-throughput detection of a wide variety of pathogenic and infectious cells.
Authors:
Ghanashyam Acharya; Chun-Li Chang; Cagri Savran
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  128     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-05-25     Revised Date:  2008-01-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3862-3     Citation Subset:  IM    
Affiliation:
School of Mechanical Engineering, and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Bacterial / chemistry
Antibody Specificity
Bacteriological Techniques / methods*
Biosensing Techniques / methods*
Escherichia coli / immunology
Pseudomonas aeruginosa / isolation & purification*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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