Document Detail

An opponent-process interpretation of the anxiolytic effects of single inhalations of large concentrations of carbon dioxide.
MedLine Citation:
PMID:  7706507     Owner:  NLM     Status:  MEDLINE    
Ten anxiety-disorder outpatients and 10 controls were monitored for heart rate and self reports of anxiety approximately 1 min before and 1 min after a single full-capacity inhalation of a gas consisting of either 65% CO2 + 35% O2 or compressed air. Under the CO2 + O2 condition, patients and controls showed almost identical reductions in anxiety and parallel reductions in heart rate. From an opponent-process point of view, these reductions were explained by the acute negative affective state being followed by the hedonically pleasant state that follows dissipation of CO2. Under the compressed air condition, only patients showed reductions of anxiety presumably because in them breathing an unknown gas via an inhalation mask, raised anxiety, followed by an opponent-process to anxiety after withdrawal of the mask.
R Ley
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of behavior therapy and experimental psychiatry     Volume:  25     ISSN:  0005-7916     ISO Abbreviation:  J Behav Ther Exp Psychiatry     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-09     Completed Date:  1995-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245075     Medline TA:  J Behav Ther Exp Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-9     Citation Subset:  IM    
University at Albany, State University of New York 12222.
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MeSH Terms
Administration, Inhalation
Anxiety Disorders / psychology,  therapy*
Arousal / drug effects*
Blood Pressure / drug effects
Carbon Dioxide / administration & dosage*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Middle Aged
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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