Document Detail


An open trial on short-term omeprazole therapy for gastric and duodenal ulcers.
MedLine Citation:
PMID:  1884955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Omeprazole, a proton pump inhibitor, is a potent and long-acting gastric acid reducing agent. To assess its short-term efficacy and safety, 27 gastric ulcers (GU) and 40 duodenal ulcers (DU) in 64 patients were treated with 20 mg. Omeprazole was given once daily. At 2 weeks, the healing rate for gastric ulcers was 66% (18/27) and for duodenal ulcers, 78% (31/40). At 4 weeks, the healing rate was 85% and 95% for GU and DU, respectively. Pain relief was achieved after 2 weeks in 62% with GU and 61% in DU. There were no significant side effects noted during the treatment course. Omeprazole is effective and safe in the treatment of gastric and duodenal ulcers.
Authors:
J D Sollano; A C Espiritu; S Z Alvarez; J Y Perez
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  26 Suppl 3     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-04     Completed Date:  1991-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Affiliation:
University of Santo Tomas, Manila, Philippines.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Drug Evaluation
Duodenal Ulcer / drug therapy*
Duodenoscopy
Female
Gastroscopy
Humans
Male
Middle Aged
Omeprazole / therapeutic use*
Stomach Ulcer / drug therapy*
Chemical
Reg. No./Substance:
73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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