| An open trial of high-dosage antioxidants in early Parkinson's disease. | |
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MedLine Citation:
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PMID: 1985415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High dosages of tocopherol and ascorbate were administered to patients with early Parkinson's disease as a preliminary open-labeled trial for the eventual controlled double-blind study evaluating antioxidants as a test of the endogenous toxin hypothesis of the etiology of Parkinson's disease. The primary endpoint of the trial was the need to treat patients with levodopa. The time when levodopa became necessary in the treated patients was compared with another group of patients followed elsewhere and not taking antioxidants. The time when levodopa became necessary was extended by 2.5 y in the group taking antioxidants. The results of this pilot study suggest that the progression of Parkinson's disease may be slowed by the administration of these antioxidants. A large multicenter, controlled clinical trial currently underway in North America evaluating tocopherol and deprenyl has the potential to confirm these results. |
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Authors:
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S Fahn |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 53 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-01 Completed Date: 1991-02-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 380S-382S Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ascorbic Acid / therapeutic use* Drug Evaluation Drug Therapy, Combination Female Humans Levodopa / therapeutic use Male Middle Aged Parkinson Disease / drug therapy* Pilot Projects Vitamin E / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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