Document Detail

An open study to compare the efficacy and tolerability of two diuretic combinations, frusemide plus amiloride and hydrochlorothiazide plus amiloride, in patients with mild to moderate essential hypertension.
MedLine Citation:
PMID:  3371085     Owner:  NLM     Status:  MEDLINE    
Forty-four patients with mild to moderate essential hypertension were entered in an open study to compare the efficacy and tolerability of the two diuretic combinations, frusemide (40 mg) plus amiloride (5 mg) and hydrochlorothiazide (50 mg) plus amiloride (5 mg), as first-line treatment. After a 2-week run-in period when no antihypertensive medication was given, patients were randomized to receive one or other combination at a dose of 1 tablet daily for 2 weeks. Patients either remained on this regimen for a further 8 weeks or, if their blood pressure was not controlled, dosage was increased to 2 tablets daily. In the latter case, patients were re-assessed after 2 weeks, and those who showed a positive response remained in the study for 8 additional weeks. In the 36 patients assessed (18 in each group), both treatments were found to reduce blood pressure effectively in a high percentage of patients treated. Hydrochlorothiazide/amiloride, however, caused a significant reduction in both plasma potassium and sodium levels whereas frusemide/amiloride did not. More adverse events were reported by patients taking frusemide/amiloride, but the majority of these were trivial.
C I Backhouse; J Platt; R J Crawford; S Allman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  10     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-12     Completed Date:  1988-07-12     Revised Date:  2010-07-23    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  690-8     Citation Subset:  IM    
Medical Department, Rorer Health Care Ltd., Eastbourne, England.
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MeSH Terms
Amiloride / adverse effects,  therapeutic use*
Drug Combinations / adverse effects,  therapeutic use
Furosemide / adverse effects,  therapeutic use*
Heart Rate / drug effects
Hydrochlorothiazide / adverse effects,  therapeutic use*
Hypertension / blood,  drug therapy*,  physiopathology
Middle Aged
Potassium / blood
Random Allocation
Reg. No./Substance:
0/Drug Combinations; 2609-46-3/Amiloride; 54-31-9/Furosemide; 58-93-5/Hydrochlorothiazide; 68529-45-3/amiloride, hydrochlorothiazide drug combination; 7440-09-7/Potassium; 92522-90-2/frumil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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