| An open study of 1.5 g naproxen daily in osteoarthritis. | |
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MedLine Citation:
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PMID: 3886299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixty-two patients requiring regular treatment for osteoarthritis were entered into a 6-month open assessment of 1.5 g naproxen daily. Fourteen patients withdrew from the study because of side-effects, 9 because of poor efficacy and 2 for a combination of these reasons. Most side-effects related to the gastro-intestinal tract and were not of a serious nature, although 1 patient had a gastro-intestinal bleed at 24 weeks. A further patient developed neutropenia, but its relationship to naproxen therapy was considered unknown. Short-term studies of 1.5 g naproxen daily have shown an increased efficacy compared to lower doses with no increase in side-effects. It is concluded that the results of this study increase the confidence with which such a dose can be used. |
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Authors:
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H Berry; A Nicholls |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Current medical research and opinion Volume: 9 ISSN: 0300-7995 ISO Abbreviation: Curr Med Res Opin Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-11 Completed Date: 1985-06-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 366-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Clinical Trials as Topic Female Humans Male Middle Aged Naproxen / administration & dosage*, adverse effects, therapeutic use Osteoarthritis / drug therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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22204-53-1/Naproxen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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