Document Detail


An open study of 1.5 g naproxen daily in osteoarthritis.
MedLine Citation:
PMID:  3886299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-two patients requiring regular treatment for osteoarthritis were entered into a 6-month open assessment of 1.5 g naproxen daily. Fourteen patients withdrew from the study because of side-effects, 9 because of poor efficacy and 2 for a combination of these reasons. Most side-effects related to the gastro-intestinal tract and were not of a serious nature, although 1 patient had a gastro-intestinal bleed at 24 weeks. A further patient developed neutropenia, but its relationship to naproxen therapy was considered unknown. Short-term studies of 1.5 g naproxen daily have shown an increased efficacy compared to lower doses with no increase in side-effects. It is concluded that the results of this study increase the confidence with which such a dose can be used.
Authors:
H Berry; A Nicholls
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Current medical research and opinion     Volume:  9     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-11     Completed Date:  1985-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Clinical Trials as Topic
Female
Humans
Male
Middle Aged
Naproxen / administration & dosage*,  adverse effects,  therapeutic use
Osteoarthritis / drug therapy*
Time Factors
Chemical
Reg. No./Substance:
22204-53-1/Naproxen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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