Document Detail

An open, randomized comparative study of a low-strength frusemide/amiloride combination and bumetanide/potassium chloride in the treatment of mild congestive cardiac failure.
MedLine Citation:
PMID:  2193839     Owner:  NLM     Status:  MEDLINE    
In an open, randomized, parallel group study lasting 8 weeks, nine males and nine females with mild congestive cardiac failure were initially treated daily with 20 mg frusemide/2.5 mg amiloride or 0.5 mg bumetanide/573 mg potassium chloride. In two patients receiving the frusemide combination and in one receiving the bumetanide combination, the daily dose was doubled after 2 weeks' treatment because of inadequate control of symptoms. Mild congestive cardiac failure symptoms (raised jugular venous pressure, oedema and dyspnoea at rest and on effort) were controlled in 9/10 patients receiving frusemide/amiloride but two patients receiving bumetanide/potassium chloride still had mild oedema after 8 weeks. Both treatments were well tolerated overall and there were no clinically significant changes in plasma electrolytes, although one patient treated with frusemide/amiloride was withdrawn due to adverse events.
D Latta; V P Finnamore; K Dalton; S Allman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  18 Suppl 2     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  10B-16B     Citation Subset:  IM    
Rorer Health Care Ltd, Eastbourne, East Sussex, UK.
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MeSH Terms
Amiloride / therapeutic use*
Blood Pressure
Bumetanide / therapeutic use*
Diuretics / therapeutic use*
Drug Combinations / therapeutic use
Furosemide / therapeutic use*
Heart Failure / drug therapy*,  physiopathology
Heart Rate
Potassium Chloride / therapeutic use*
Reg. No./Substance:
0/Diuretics; 0/Drug Combinations; 2609-46-3/Amiloride; 28395-03-1/Bumetanide; 54-31-9/Furosemide; 7447-40-7/Potassium Chloride; 92522-90-2/frumil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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