Document Detail


An open, randomized, comparative study of clarithromycin and erythromycin in the treatment of children with community-acquired pneumonia.
MedLine Citation:
PMID:  18327427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: This study aimed to evaluate the efficacy and safety of clarithromycin and erythromycin in the treatment of community-acquired pneumonia in children. METHODS: Children with community-acquired pneumonia were randomly assigned to receive 10-day regimens of either clarithromycin 15 mg/kg/day, twice a day, or erythromycin 30-50 mg/kg/day, four times daily. RESULTS: A total of 97 children entered this study, including 26 with Mycoplasma pneumoniae infection, 15 with Chlamydia pneumoniae infection, and 6 with mixed mycoplasma and chlamydia infections. Fifty and 47 children received clarithromycin and erythromycin treatment, respectively. Three children withdrew from the study because the identified pathogens were resistant to the study drugs. All 47 children with mycoplasma or chlamydia infection were cured clinically. Delayed defervescence, defined as a fever lasting for more than 72 h after treatment, was observed in 4 of 22 clarithromycin-treated children (18%) and in 3 of 15 erythromycin-treated children (20%) [p>0.05]. Gastrointestinal side effects, including vomiting, abdominal pain and diarrhea, were observed in 3 of 50 children (6%) receiving clarithromycin and in 11 of 49 children (22%) receiving erythromycin (p=0.039). Excluding children with abnormal pretreatment liver function, abnormal liver function after treatment was observed in only one child, treated with erythromycin. Post-treatment eosinophil and platelet counts were significantly elevated after treatment in both groups. CONCLUSIONS: Clarithromycin showed efficacy equivalent to erythromycin for the treatment of mycoplasma or chlamydia pneumonia in children. However, the tolerability of clarithromycin was superior to that of erythromycin.
Authors:
Ping-Ing Lee; Mei-Hwan Wu; Li-Min Huang; Jong-Min Chen; Chin-Yun Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi     Volume:  41     ISSN:  1684-1182     ISO Abbreviation:  J Microbiol Immunol Infect     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956211     Medline TA:  J Microbiol Immunol Infect     Country:  China    
Other Details:
Languages:  eng     Pagination:  54-61     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. pinging@ntumc.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Bacterial Agents / administration & dosage*,  adverse effects
Child
Child, Preschool
Chlamydia Infections / drug therapy
Clarithromycin / administration & dosage*,  adverse effects
Community-Acquired Infections / drug therapy*,  microbiology
Drug Administration Schedule
Drug Toxicity
Erythromycin / administration & dosage*,  adverse effects
Female
Humans
Infant
Infant, Newborn
Male
Mycoplasma Infections / drug therapy
Pneumonia / drug therapy*,  microbiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 114-07-8/Erythromycin; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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