| An open label, single-centre, randomized trial of spinal cord stimulation vs. percutaneous myocardial laser revascularization in patients with refractory angina pectoris: the SPiRiT trial. | |
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MedLine Citation:
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PMID: 16554313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Refractory angina pectoris leads to significant morbidity. Treatment options include percutaneous myocardial laser revascularization (PMR) and spinal cord stimulation (SCS). This study was designed to compare these two treatments. METHODS AND RESULTS: Subjects with Canadian Cardiovascular Society (CCS) class 3/4 angina and reversible perfusion defects were randomized to SCS (34) or PMR (34). The primary outcome was to compare exercise treadmill time on a modified Bruce protocol over 12 months. Thirty subjects in both groups completed 12-month follow-up. The mean total exercise time was 6.38 +/- 3.45 min in the SCS group and 7.41+/-3.68 min in the PMR group at baseline and 7.08 +/- 0.67 min in the SCS group and 7.12 +/-0.71 min in the PMR group at 12 months (95% confidence limits for the difference between the groups -1.02 to + 2.2 min, P = 0.466). There were no differences in angina-free exercise capacity, CCS class, and quality of life between treatments. SCS patients had more adverse events in the first 12 months, mainly angina or SCS system related (P = 0.001). CONCLUSION: There was little evidence of a difference in effectiveness between SCS and PMR in patients with refractory angina. |
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Authors:
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Duncan McNab; Sadia N Khan; Linda D Sharples; Judy Y Ryan; Carol Freeman; Noreen Caine; Sue Tait; Ian Hardy; Peter M Schofield |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-03-22 |
Journal Detail:
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Title: European heart journal Volume: 27 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2006-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1048-53 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Papworth Hospital NHS Trust, Papworth Everard, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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therapy* Exercise Tolerance Female Humans Laser Therapy / methods* Male Middle Aged Myocardial Revascularization / methods* Quality of Life Transcutaneous Electric Nerve Stimulation / methods* Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2006 May;27(9):1007-9
[PMID:
16554312
]
Eur Heart J. 2006 Jul;27(13):1631-2; author reply 1632 [PMID: 16751209 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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