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An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder.
MedLine Citation:
PMID:  21314450     Owner:  NLM     Status:  In-Data-Review    
Abstract Objective: Despite the data that major depressive disorder (MDD) is common during pregnancy and that pregnant women prefer nonmedication treatment options, there is a paucity of research examining alternative treatments for this special population. We present the results of an open label pilot study examining treatment with transcranial magnetic stimulation (TMS) in pregnant women with MDD. Methods: Ten women with MDD in the second or third trimester of pregnancy were treated with 20 sessions of 1-Hz TMS at 100% of motor threshold (MT) to the right dorsolateral prefrontal cortex. The total study dose was 6000 pulses. Antenatal monitoring was performed during treatment sessions 1, 10, and 20. Results: Seven of ten (70%) subjects responded (decrease ≥50% in Hamilton Depression Rating Scale [HDRS-17] scores). No adverse pregnancy or fetal outcomes were observed. All infants were admitted to the well baby nursery and were discharged with the mother. Mild headache was the only common adverse event and was reported by 4 of 10 (40%) subjects. Conclusions: TMS appears to be a promising treatment option for pregnant women who do not wish to take antidepressant medications.
Deborah R Kim; Neill Epperson; Emmanuelle Paré; Juan M Gonzalez; Samuel Parry; Michael E Thase; Pilar Cristancho; Mary D Sammel; John P O'Reardon
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  20     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
1 Department of Psychiatry, University of Pennsylvania , Philadelphia, Pennsylvania.
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