Document Detail

The ontogeny of postingestive inhibitory stimuli: examining the role of CCK.
MedLine Citation:
PMID:  16770766     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK) inhibits food intake in adults. This paper describes research examining the ability of CCK to affect feeding in infant rats and the role of CCK in the developmentally emerging ability of the rat pup to inhibit ingestion in response to sensory characteristics of food. First, data will be described from studies that asked if the CCK system is functional in preweanling rats. Specifically, these studies examined whether exogenous and endogenous CCK can decrease intake of the infant rat during independent ingestion (of a milk diet, away from the dam). In addition, the ability of exogenous CCK to activate central feeding-control areas in the brain stem and hypothalamus in infant rats was examined by C-FOS staining. Next, experiments examining which specific intake-inhibitory sensory aspects of food are mediated by CCK will be described. The volume, hypertonicity, fat, carbohydrate and protein content of a preload were separately manipulated in different studies, followed closely by a 30-min test meal. The selective CCK(1) receptor antagonist devazepide was used to assess CCK mediation of the control of intake produced by particular sensory aspects of food, at the earliest age in which this ability to control intake appears. Finally, the pattern of independent ingestion in infant OLETF rats lacking CCK(1) receptors was examined. The results suggest that the CCK intake-inhibitory mechanism is potentially available to the young, suckling pup even before it starts to feed on its own. However, it appears to mediate only a portion of the controls of intake during nursing and early stages of weaning. Some aspects of the CCK system (e.g., forebrain-hindbrain connections) and CCK's role in mediating the effects of other stimulus aspects of food apparently undergo a post-weaning maturational process.
Aron Weller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Developmental psychobiology     Volume:  48     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-79     Citation Subset:  IM    
Department of Psychology, and the Gonda Goldschmied Brain Research Center, Bar Ilan University, Ramat Gan, Israel.
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MeSH Terms
Brain / drug effects,  metabolism
Cholecystokinin / metabolism,  physiology*
Devazepide / administration & dosage,  pharmacology
Dietary Fats
Eating / physiology*
Feeding Behavior
Hormone Antagonists / administration & dosage,  pharmacology
Inhibition (Psychology)*
Proto-Oncogene Proteins c-fos / drug effects,  metabolism
Receptors, Cholecystokinin / drug effects
Sincalide / metabolism
Reg. No./Substance:
0/Carbohydrates; 0/Dietary Fats; 0/Hormone Antagonists; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Cholecystokinin; 103420-77-5/Devazepide; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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