Document Detail


A one-year survey of candidemia in Belgium in 2002.
MedLine Citation:
PMID:  15635977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 211 episodes of bloodstream yeast infections in 207 patients, hospitalized in 28 Belgian hospitals participating in a National Surveillance Program, were evaluated. A total of 81% of the patients were more than 50 years of age. Candida albicans was the cause of infections in 55% of patients, 22% were due to C. glabrata and 13% to C. parapsilosis. The most common predisposing factors were antibacterial therapy (42%), residence in an intensive care unit (32.9%) and presence of an intravascular catheter (29.7%). Most patients had more than one predisposing factor. Fluconazole alone or in association with another antifungal agent was the treatment of choice for 89.7% of the cases. In vitro susceptibility testing of the isolates revealed that 99% were susceptible to amphotericin B, 95% to 5-fluorocytosine, 82% to fluconazole and 69% to itraconazole. Resistance to azoles was more common among C. glabrata isolates in the elderly. We conclude that the frequency of C. albicans infection is decreasing in Belgium and this is associated with the emergence of other species, most notably, C. glabrata.
Authors:
D Swinne; M Watelle; C Suetens; K Mertens; P A Fonteyne; N Nolard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology and infection     Volume:  132     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-07     Completed Date:  2005-01-26     Revised Date:  2010-05-17    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1175-80     Citation Subset:  IM    
Affiliation:
Mycology Section, Scientific Institute of Public Health, Brussels, Belgium. d.swinne@iph.fgov.be
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antifungal Agents / therapeutic use
Belgium / epidemiology
Candida albicans / drug effects,  pathogenicity
Candida glabrata / drug effects,  pathogenicity
Candidiasis / drug therapy,  epidemiology*,  therapy
Drug Resistance, Fungal
Female
Fungemia / drug therapy,  epidemiology*,  therapy
Hospitalization / statistics & numerical data
Humans
Incidence
Male
Middle Aged
Population Surveillance*
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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