Document Detail

The one-stop recurrent miscarriage clinic: an evaluation of its effectiveness and outcome.
MedLine Citation:
PMID:  15388685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Couples with recurrent miscarriages make several visits to specialized clinics for investigations before treatment is offered. Consequently, 'the interval' between receipt of referral and advice to try for a pregnancy is often lengthy. The objectives of this study were to examine the effect of a 'one-stop' clinic on 'the interval', throughput and the outcome from this clinic. METHODS: The processes for investigation, management and outcomes of 189 couples seen in our Recurrent Miscarriage Clinic (RMC) and their records were reviewed. RESULTS: The one-stop clinic reduced the interval and number of visits by 36% (206.6 to 130.4 days, P < 0.001) and by 60% (2.5 to 1, P < 0.002) respectively. The prevalence and frequency of aetiological factors were similar in those with two and three or more miscarriages (41% versus 45%, P > 0.05). The commonest aetiological factors were thrombophilias (14%) and antiphospholipid syndrome (11%). No cause was identified in 54% of cases. The pregnancy and live birth rates were best in the idiopathic group (75%), those with thrombophilias (64%) and autoimmune antibodies (83%). Older couples had the worse pregnancy rates and outcome. CONCLUSION: A one-stop clinic significantly shortens 'the interval' between referral and initiation of treatment. Investigations should be initiated in women after two consecutive miscarriages.
Osama M H Habayeb; Justin C Konje
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Publication Detail:
Type:  Journal Article     Date:  2004-09-23
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  19     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-05-31     Revised Date:  2006-01-27    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2952-8     Citation Subset:  IM    
Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK.
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MeSH Terms
Abortion, Habitual / prevention & control,  therapy*
Antiphospholipid Syndrome / diagnosis,  therapy
Birth Rate
Maternal Age
Pregnancy Complications / diagnosis*,  therapy
Pregnancy Rate
Prenatal Care / methods,  organization & administration*
Thrombophilia / diagnosis,  therapy
Treatment Outcome
Comment In:
Hum Reprod. 2005 Oct;20(10):2976-9   [PMID:  16183996 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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