Document Detail


ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via STAT5 activation in the acute promyelocytic cell line HT93A.
MedLine Citation:
PMID:  25373509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract We investigated the role of ETV6/ARG fusion genes by exposing the HT93A cell line to nilotinib. HT93A cells were cultured with or without nilotinib ± 50 ng/ml of granulocyte colony-stimulating factor (G-CSF). Nilotinib treatment inhibited cell growth by increasing the percentage of cells in the G0/G1 phase through the decrease of phosphorylated STAT3 (Y705), STAT5 (Y694), and c-Myc expression. After stimulation with G-CSF, STAT5 but not STAT3 was significantly phosphorylated in both nilotinib-treated and untreated cells. Moreover, combination therapy with nilotinib and G-CSF returned the expression level of c-Myc, cell growth, and cell cycle distribution to the control level. These findings suggest that the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the upregulation of c-Myc. Our data suggest that ETV6/ARG oncoprotein is a potential target in the treatment of leukemia.
Authors:
Noriyoshi Iriyama; Yoshihiro Hatta; Masami Takei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-5
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-6     Completed Date:  -     Revised Date:  2014-11-7    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-26     Citation Subset:  -    
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