Document Detail

An old drug for a new application: potential benefits of sildenafil in wound healing.
MedLine Citation:
PMID:  23106952     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed.
METHODS: A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were 'phosphodiesterase inhibitor', 'sildenafil', 'skin', 'cutaneous', 'skin lesion', 'skin damage', 'wound', and 'wound healing'. No time limitation was considered in this review.
RESULTS: A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease.
CONCLUSIONS: The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
Shadi Farsaie; Hossein Khalili; Iman Karimzadeh; Simin Dashti-Khavidaki
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques     Volume:  15     ISSN:  1482-1826     ISO Abbreviation:  J Pharm Pharm Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-06-19     Revised Date:  2013-09-11    
Medline Journal Info:
Nlm Unique ID:  9807281     Medline TA:  J Pharm Pharm Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  483-98     Citation Subset:  IM    
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Piperazines / pharmacology*,  therapeutic use*
Purines / pharmacology,  therapeutic use
Sulfones / pharmacology*,  therapeutic use*
Wound Healing / drug effects*
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 3M7OB98Y7H/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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