Document Detail


The oestrogenic effects of ethinyl oestradiol/polyoestradiol phosphate and estramustine phosphate in patients with prostatic carcinoma. A comparative study of oestrogen sensitive liver proteins, gonadotrophins and prolactin.
MedLine Citation:
PMID:  3092893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty previously untreated patients with carcinoma of the prostate were prospectively randomised to one of the following treatments: ethinyl oestradiol (Etivex) combined with polyoestradiol phosphate (Estradurin); estramustine phosphate (Estracyt); bilateral orchiectomy. Oestrogenic effects were measured by blood levels of pregnancy zone protein, sex hormone binding globulin, LH, FSH and prolactin. During a follow-up period of 6 months, estramustine phosphate and ethinyl oestradiol/polyoestradiol phosphate induced comparable changes in these proteins, suggesting comparable oestrogenic effects of these two forms of treatment in patients with prostatic carcinoma.
Authors:
L Daehlin; J E Damber; B von Schoultz; B Bergman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of urology     Volume:  58     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  412-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Combined Chemotherapy Protocols
Estradiol / analogs & derivatives*,  therapeutic use
Estramustine / therapeutic use*
Ethinyl Estradiol / therapeutic use*
Follicle Stimulating Hormone / metabolism
Humans
Luteinizing Hormone / metabolism
Male
Middle Aged
Nitrogen Mustard Compounds / therapeutic use*
Orchiectomy
Pregnancy Proteins / metabolism
Prolactin / metabolism
Prostatic Neoplasms / drug therapy*,  metabolism
Sex Hormone-Binding Globulin / metabolism
Chemical
Reg. No./Substance:
0/Nitrogen Mustard Compounds; 0/Pregnancy Proteins; 0/Sex Hormone-Binding Globulin; 28014-46-2/polyestradiol phosphate; 2998-57-4/Estramustine; 50-28-2/Estradiol; 57-63-6/Ethinyl Estradiol; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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