Document Detail


An odorant-binding protein required for suppression of sweet taste by bitter chemicals.
MedLine Citation:
PMID:  23972598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animals often must decide whether or not to consume a diet that contains competing attractive and aversive compounds. Here, using the fruit fly, Drosophila melanogaster, we describe a mechanism that influences this decision. Addition of bitter compounds to sucrose suppressed feeding behavior, and this inhibition depended on an odorant-binding protein (OBP) termed OBP49a. In wild-type flies, bitter compounds suppressed sucrose-induced action potentials, and the inhibition was impaired in Obp49a mutants. However, loss of OBP49a did not affect action potentials in sugar- or bitter-activated gustatory receptor neurons (GRNs) when the GRNs were presented with just one type of tastant. OBP49a was expressed in accessory cells and acted non-cell-autonomously to attenuate nerve firings in sugar-activated GRNs when bitter compounds were combined with sucrose. These findings demonstrate an unexpected role for an OBP in taste and identify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs.
Authors:
Yong Taek Jeong; Jaewon Shim; So Ra Oh; Hong In Yoon; Chul Hoon Kim; Seok Jun Moon; Craig Montell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  79     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-26     Completed Date:  2013-11-04     Revised Date:  2014-08-22    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-37     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology
Analgesics, Non-Narcotic / pharmacology
Animals
Animals, Genetically Modified
Choice Behavior / drug effects,  physiology
Dose-Response Relationship, Drug
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster
Electrodes
Food Preferences / drug effects,  physiology
Green Fluorescent Proteins / genetics,  metabolism
Mutation / genetics
Odors*
Quaternary Ammonium Compounds / pharmacology
Quinine / pharmacology
Receptors, Odorant / genetics*,  metabolism*
Sensilla / drug effects,  physiology
Sucrose / administration & dosage
Sweetening Agents / pharmacology
Taste / drug effects*,  genetics*
Transcription Factors / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
DC007864/DC/NIDCD NIH HHS; R01 DC007864/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Drosophila Proteins; 0/GAL4 protein, Drosophila; 0/Quaternary Ammonium Compounds; 0/Receptors, Odorant; 0/Sweetening Agents; 0/Transcription Factors; 0/odorant-binding protein; 0W5171805N/denatonium chloride; 147336-22-9/Green Fluorescent Proteins; 57-50-1/Sucrose; A7V27PHC7A/Quinine
Comments/Corrections
Comment In:
Neuron. 2013 Aug 21;79(4):612-4   [PMID:  23972590 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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