Document Detail

The occurrence of perfluorinated alkyl compounds in human milk from different regions of China.
MedLine Citation:
PMID:  20400180     Owner:  NLM     Status:  MEDLINE    
Perfluorinated compounds (PFCs), especially perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), are known to occur throughout the environment and in the human population (Houde et al., 2006). The occurrence of PFCs in human umbilical cord blood and human milk, coupled with the potential developmental toxicity of PFCs, suggests the need for determining the exposure sources and magnitudes of PFCs in infants. In this study, 10 PFCs were measured in 24 pooled samples consisting of 1237 individual human milk samples. The samples were collected from 12 provinces of China in 2007. PFOS and PFOA were the predominant PFCs found in all the samples tested. The geometric mean (GM) and median of the concentrations were 46 pg/mL and 49 pg/mL for PFOS, 46 pg/mL and 34.5 pg/mL for PFOA respectively. A large variation in geographical distribution was observed for PFCs in human milk. High concentrations of PFOA (814 pg/ml for the rural samples and 616 pg/ml for the urban samples) were found in human milk from Shanghai. Estimated dietary intakes (EDI) were established and the median, GM and the highest EDI of the total PFCs were 17.2 ng/kg/d, 17.8 ng/kg/d and 129.1 ng/kg/d respectively. The EDI for PFOA (88.4 ng/kg/d) for Shanghai was close to the tolerable daily intake (100 ng/kg/d) proposed by the German Federal Institute for Risk Assessment and the Drinking Water Commission. The results suggest both mothers and infants have a high exposure to PFCs in the Shanghai region. The potential health impact of postnatal exposure through breastfeeding to infants should therefore be comprehensively evaluated.
Jiaying Liu; Jingguang Li; Yunfeng Zhao; Yuxin Wang; Lei Zhang; Yongning Wu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-18
Journal Detail:
Title:  Environment international     Volume:  36     ISSN:  1873-6750     ISO Abbreviation:  Environ Int     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  433-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
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MeSH Terms
Environmental Exposure
Environmental Pollutants / analysis*
Fluorocarbons / analysis*
Milk, Human / chemistry*
Young Adult
Reg. No./Substance:
0/Environmental Pollutants; 0/Fluorocarbons

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