Document Detail


An observational study of vasopressin infusion during uncontrolled haemorrhagic shock in a porcine trauma model: Effects on bowel function.
MedLine Citation:
PMID:  17097209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of vasopressin on the gut in a porcine uncontrolled haemorrhagic shock model are described. In eight anaesthetised pigs, a liver laceration was performed; when haemorrhagic shock was decompensated, all animals received 0.4 IU/kg vasopressin, followed by 0.08 IU/kg min over 30 min, which maintained a mean arterial blood pressure >40 mmHg. Subsequent surgical intervention, infusion of whole blood and fluids resulted in a stable cardiocirculatory status. Three hours after stabilisation, all pigs developed non-bloody diarrhoea which converted into normal bowel movements within 24 h. All histological samples retained 7 days after the experiment revealed no histopathological changes. In conclusion, in this small observational study of uncontrolled porcine haemorrhagic shock, a resuscitation strategy that included high dose vasopressin was associated with transient diarrhoea and good long term survival.
Authors:
Karl H Stadlbauer; Volker Wenzel; Horst G Wagner-Berger; Anette C Krismer; Alfred Königsrainer; Wolfgang G Voelckel; Claus Raedler; Christian A Schmittinger; Karl H Lindner; Guenter Klima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-09
Journal Detail:
Title:  Resuscitation     Volume:  72     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-04-24     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. karl-heinz.stadlbauer@uibk.ac.at
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Diarrhea / physiopathology
Disease Models, Animal
Intestines / drug effects*,  physiopathology*
Liver / injuries
Shock, Hemorrhagic / drug therapy*,  physiopathology
Swine
Vasoconstrictor Agents / pharmacology,  therapeutic use*
Vasopressins / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 11000-17-2/Vasopressins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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