| An objective marker of lactate-induced panic. | |
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MedLine Citation:
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PMID: 3432458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are a number of agents claimed effective in provoking panic attacks in the laboratory. For each case, however, the determination of whether an attack has occurred is largely subjective. An objective index of panic would be of great benefit in standardizing laboratory provocation studies. Using heart rate (HR) recordings during sodium lactate infusion, we developed a formula--the heart rate index (HRI)--which appears to correlate well with the subjective experience of panic. Of note is the fact that the HRI was most powerful in identifying attacks that occurred in the first 15 min of the 20-min infusions. In an accompanying study, we examined HR variability during the infusions using the successive difference mean square statistic. HR variability did not change during lactate-induced panic attacks. Therefore, tachycardia during lactate-induced panic probably does not result from decreased vagal tone to the heart. |
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Authors:
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J M Gorman; M Davies; R Steinman; M R Liebowitz; A J Fyer; J Coromilas; D F Klein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 22 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-03-24 Completed Date: 1988-03-24 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: IRELAND |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Biological Studies Unit, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, NY. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety Disorders / chemically induced*, diagnosis Fear* / drug effects Female Heart Rate / drug effects* Humans Lactates* / pharmacology Lactic Acid Male Panic* / drug effects Stimulation, Chemical Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MH-00416/MH/NIMH NIH HHS; MH-903-1163C/MH/NIMH NIH HHS; MHCR-903-C006/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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