Document Detail

An objective assessment of the physiologic changes in the postthrombotic syndrome.
MedLine Citation:
PMID:  3885908     Owner:  NLM     Status:  MEDLINE    
To determine what physiologic changes might contribute to the development of the postthrombotic syndrome, venous outflow, venous refilling time, and valvular competence were assessed in 32 patients (39 limbs) with documented deep venous thrombosis. The follow-up ranged from nine to 144 months (mean, 41 months) after the acute deep venous thrombosis. Pain was noted by 49% of the patients, but more objective end points occurred less frequently (edema, 21%; pigmentation, 26%; ulceration, 3%). Venous outflow was lower in the affected limbs but was not a good indicator of those patients with or without symptoms. Venous refilling time after calf compression was markedly reduced in limbs with incompetent valves (mean +/- SD, 8.4 +/- 3.8 s v 25.3 +/- 12.1 s), as well as in those with edema, pigmentation, and ulceration. It appears that most of the sequelae of the postthrombotic syndrome can be attributed to the loss of valvular function.
L A Killewich; R Martin; M Cramer; K W Beach; D E Strandness
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  120     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-04-29     Completed Date:  1985-04-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-6     Citation Subset:  AIM; IM    
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MeSH Terms
Edema / etiology,  physiopathology*
Follow-Up Studies
Leg / blood supply
Middle Aged
Pain / etiology,  physiopathology*
Prospective Studies
Regional Blood Flow
Thrombophlebitis / complications,  physiopathology*
Veins / physiopathology
Grant Support
20381//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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