| An objective assessment of the physiologic changes in the postthrombotic syndrome. | |
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MedLine Citation:
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PMID: 3885908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine what physiologic changes might contribute to the development of the postthrombotic syndrome, venous outflow, venous refilling time, and valvular competence were assessed in 32 patients (39 limbs) with documented deep venous thrombosis. The follow-up ranged from nine to 144 months (mean, 41 months) after the acute deep venous thrombosis. Pain was noted by 49% of the patients, but more objective end points occurred less frequently (edema, 21%; pigmentation, 26%; ulceration, 3%). Venous outflow was lower in the affected limbs but was not a good indicator of those patients with or without symptoms. Venous refilling time after calf compression was markedly reduced in limbs with incompetent valves (mean +/- SD, 8.4 +/- 3.8 s v 25.3 +/- 12.1 s), as well as in those with edema, pigmentation, and ulceration. It appears that most of the sequelae of the postthrombotic syndrome can be attributed to the loss of valvular function. |
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Authors:
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L A Killewich; R Martin; M Cramer; K W Beach; D E Strandness |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 120 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-04-29 Completed Date: 1985-04-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 424-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Edema / etiology, physiopathology* Female Follow-Up Studies Humans Leg / blood supply Male Middle Aged Pain / etiology, physiopathology* Plethysmography Prospective Studies Regional Blood Flow Syndrome Thrombophlebitis / complications, physiopathology* Ultrasonography Veins / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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20381//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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