Document Detail

The nuts and bolts of germ-cell migration.
MedLine Citation:
PMID:  20947321     Owner:  NLM     Status:  In-Data-Review    
In many species, primordial germ cells (PGCs) migrate from the position where they are specified to the site where the gonad develops, where they differentiate into sperm and egg. Germ cells thus serve as an excellent model for studying cell migration in the context of the live organism. In recent years, a number of cues directing the migration of the cells towards their target were identified and some of the relevant molecules and biochemical pathways were revealed. In this review we present those results, focusing on 'cell mechanics' of the process including cell adhesion, traction generation and cell polarization.
Katsiaryna Tarbashevich; Erez Raz
Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  Current opinion in cell biology     Volume:  22     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  715-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Institute of Cell Biology, Center for Molecular Biology of Inflammation, Von-Esmarch-Str. 56, 48149, Münster University, 48147 Münster, Germany.
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