Document Detail

The nutritional contribution to bovine spongiform encephalopathy.
MedLine Citation:
PMID:  2038456     Owner:  NLM     Status:  MEDLINE    
Evidence that changes in feeding style alter the membrane fatty acid composition of ruminant tissue is presented here by comparing zoo giraffe with the same species from their natural habitat. The membrane changes seen are similar to those used experimentally to make animals susceptible to basic brain protein and encephalomalacia. Similar membrane responses have been noted in cattle. Use of animal protein and increased nitrogen in cattle feeds would lead to a relative deficiency of essential fatty acids in the cell membranes and hence reduced membrane stability. By analogy with crazy chick disease (nutritional encephalomalacia) and experimental encephalomyelitis in rats, the possibility that the changes in animals feeds would have depleted cattle tissue membranes and made them susceptible to BSE is discussed. The assumption being made is that the principle of a requirement of essential fatty acids for neural integrity and immune system function would apply to cattle as well as to other species.
M A Crawford; P Budowski; P Drury; K Ghebremeskel; L Harbige; M Leighfield; A Phylactos; G Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition and health     Volume:  7     ISSN:  0260-1060     ISO Abbreviation:  Nutr Health     Publication Date:  1991  
Date Detail:
Created Date:  1991-06-28     Completed Date:  1991-06-28     Revised Date:  2012-02-23    
Medline Journal Info:
Nlm Unique ID:  8306569     Medline TA:  Nutr Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Institute of Brain Chemistry and Human Nutrition, London.
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MeSH Terms
Animal Feed*
Brain Chemistry
Brain Diseases / etiology,  veterinary*
Cattle Diseases / etiology*
Cell Membrane / chemistry
Dietary Proteins
Encephalomalacia / etiology,  veterinary
Encephalomyelitis / etiology,  veterinary
Fatty Acids, Essential / deficiency*
Great Britain
Linolenic Acids / deficiency
Neurons / chemistry
Nutritional Requirements
Poultry Diseases / etiology
Slow Virus Diseases / etiology,  veterinary*
Reg. No./Substance:
0/Dietary Proteins; 0/Fatty Acids, Essential; 0/Linolenic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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